Concerns have been raised over the long-term use of nutritional supplements containing chromium, after an Australian research team found the supplement is partially converted into a carcinogenic form when it enters cells.
Chromium is a trace mineral found primarily in two forms. Trivalent chromium(III) picolinate and a range of other chromium(III) forms are sold as a nutritional supplements, while hexavalent chromium(VI) is its 'carcinogenic cousin.’
The latter gained notoriety from the book and 2000 movie, Erin Brockovich, which linked an elevated cluster of illnesses, including cancer, to hexavalent chromium in the drinking water of the Californian town of Hinkley.
Controversy remains over whether the dietary form of chromium is essential for humans, with an increasing body of evidence indicating it is not safe for humans.
Supplements containing chromium are consumed for the purported treatment of metabolic disorders, such as insulin resistance and type 2 diabetes. Supplements containing chromium are also commonly used for weight loss and body building with some containing up to 500 micrograms per tablet.
The US National Academy of Sciences has estimated up to 200 micrograms of chromium is a safe and adequate daily dietary intake for adults. Australia's current National Health and Medical Research Council Nutrient Reference Values, which are currently under review, recommend 25-35 micrograms of chromium daily as an 'adequate intake' for adults.
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