Very Low-Density What Is
Plasma lipoproteins are classified according to their density into chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). Very low-density lipoprotein (VLDL) is classified with a Svedberg flotation ultracentrifugation coefficient (Sf) that floats between densities of 0.952 and 1.006 g/mL. VLDL is further divided into three subfractions: VLDL1 (Sf 60–400), VLDL2 (Sf 20–60), and VLDL3 (Sf < 20). VLDL transports endogenous triglycerides from the liver to adipose tissue.
VLDL represents the major pathway of transport of lipids synthesized in the liver to peripheral tissues. Its composition is about 55% triglycerides, 20% cholesterol, and 22% phospholipids, and its apoprotein content is Apo B-100 and C, E. VLDL is rapidly hydrolyzed by lipoprotein lipase in the capillaries of peripheral tissues whereby triglycerides are taken up by adipocytes and muscles, leaving remnants that are further catabolized.
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