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How HIV Treatment Can Cause Weight Gain

HIV treatment can cause weight gain due to several factors:

1. Increased Appetite: Some HIV medications, particularly protease inhibitors, can lead to an increase in appetite. This can result in a higher calorie intake and potential weight gain.

2. Lipodystrophy: Lipodystrophy is a metabolic complication of HIV infection or its treatment. It affects fat distribution in the body and can lead to abnormal fat accumulation in certain areas (e.g., abdomen, chest, and face) while causing fat loss in others (e.g., limbs). This redistribution can contribute to weight gain.

3. Insulin Resistance: Certain HIV medications, especially protease inhibitors, can interfere with insulin sensitivity, leading to insulin resistance. This can result in higher blood sugar levels and increased fat storage.

4. Decreased Physical Activity: HIV infection can cause fatigue, weakness, and other symptoms that may lead to reduced physical activity. A sedentary lifestyle can contribute to weight gain.

5. Emotional Factors: Living with HIV can be stressful, leading to emotional eating or unhealthy coping mechanisms that may involve excessive food consumption.

6. Medications for Opportunistic Infections: Some medications used to treat opportunistic infections associated with HIV, such as steroids, can also contribute to weight gain.

It is essential for people living with HIV to consult their healthcare provider regularly to discuss their weight and other health-related concerns, as well as to receive appropriate guidance on diet, exercise, and lifestyle modifications to manage weight and maintain overall well-being.

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