T3 Liothyronine is a form of thyroid hormone used to treat hypothyroidism and myxedema coma. T3 is marketed as the sodium salt under the brand name Cytomel.
Liothyronine is the most potent form of thyroid hormone. As such, T3 acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
In comparison to levothyroxine (T4), liothyronine (T3) has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
Thyroid hormones regulate many body systems, including metabolism. One thyroid hormone is triiodothyroxine, also known as T3. When thyroid hormones are not in balance, certain health conditions can develop. When thyroid hormones are too low, this condition is called hypothyroidism. Thyroid medications to replace T3 and T4 can relieve some symptoms of hypothyroidism. Some patients with hypothyroidism find it easier to lose weight when they take such medications
**Uses
Physicians can use T3 instead of levothyroxine (T4) for patients undergoing thyroid withdrawal. When a patient has thyroid cancer or Grave's, I-131 ablation therapy can be used to remove any trace thyroid tissue. In order for I-131 therapy to be effective, the trace thyroid tissue must be avid to iodine. The best method is to starve the tissue of iodine but this can lead to hypothyroid symptoms for the patient. Withdrawal from levothyroxine can be done but it takes 6 weeks of withdrawal for the remaining thyroid tissue to be completely starved. 6 weeks is needed owing to levothyroxine's long half life. 6 weeks can be inconvenient for the patient and delay treatment. Liothyronine (T3) instead can be taken and withdrawn from for 2 weeks to starve the thyroid tissue. This is much safer and more convenient than levothyroxine.
Cytomel T3 Weight Loss
Natural T3 is a regulator of the oxidative metabolism of energy producing substrates (food or stored substrates like fat, muscle, and glycogen) by the mitochondria. The mitochondria, as you will recall from your high school biology class, are usually referred to as the "cells powerhouses" because they produce ATP. Taking Cytomel (supplemental T3) greatly increases the uptake of nutrients into the mitochondria and also their oxidation rate (i.e. the rate at which they are burned for energy), by increasing the activities of the enzymes involved in the oxidative metabolic pathway. Everything is working harder, in other words, and more fuel is needed to supplement this increased work rate. Therefore, as you can guess, taking supplemental Cytomel will increase your bodys energy demands. And if you are in a hypocaloric state, you will begin burning even fatter primarily due to an increase in ATP. This increased ATP causes an increase in overall metabolic activity. This is exactly what we want, and is why we would be taking thyroid hormones like Cytomel in the first place. If you arent taking anabolic steroids with your Cytomel, however, your body may start to eat away muscle to provide energy for you to function. Remember mitochondria/ATP arent very picky, but they are very efficient. What is meant by this is that they will use whatever is on hand to generate energy for your body to continue functioning, fat, protein, glucose; it doesnt matter to ATP, as long as there's something to give them energy. Taking this drug will increase their need to find something to burn to create this energy. Ergo, if we aren't taking anabolic steroids while taking our T3, we may lose too much muscle, especially while dieting. The other issue then becomes that anabolic steroid use is illegal in the USA and many other countries. Please follow all laws regarding anabolic steroid usage or any drug on this page.
T3 + Exercise
Combine regular exercise with T3 medication to achieve the best weight loss results, recommends the University of Maryland Medical Center. Exercise for at least 150 minutes weekly, or a half-hour on most days of the week. Engage in moderate-intensity aerobic exercise, such as walking, swimming and dancing. Add light resistance training, such as lifting weights or Pilates, twice per week to build muscle tone. Muscle burns more calories than fat. Cytomel aka T3 is sought out for these uses.
T3 Side Effects
Unfortunately, in all of the studies I've seen, T3 also increased growth hormone production. As we all know, GH is also a strongly lipolytic compound, and this is another mechanism by which T3 may exert its effects, although I suspect this would only be a small percentage of its overall effects. This being the case, it has always been somewhat problematic to me to note that when GH and T3 are used together, the increased nitrogen retention normally found with GH use is negated. If you were only using T3 and GH this may be a problem, but as I've already stated, you are going to need some anabolic agents if you are using T3. A popular mix is the veritable anabolic/lipolytic orgy of Insulin, T3, Anabolic Steroids, GH, and insulin, for 100% maximum results in minimal time. Now this is only for countries where the above are legal.
On the brighter side, and of special note to dieters, administration of T3 has been shown to up-regulate the beta 2 receptors in fat tissue. As you know clenbuterol and similar compounds down-regulate this receptor, so using T3 with your clen will help stave off or reverse this down-regulation. Warnings
Although T3 can make it easier to lose weight, you should not take this medication for the sole purpose of losing weight. You should also start slowly with the medication, not increasing the dosage too quickly or exceeding the prescribed dosage. T3 medications can cause serious side effects, including heart palpitations, chest pain, shaking, agitation and shortness of breath.
**Let's face it, drugs work. They improve muscle mass, strength, and athletic performance. But for many reasons drug use by athletes (or anyone) is a serious problem. Not only are there moral and health ramifications to the use of performance-enhancing drugs by athletes, but for substances such as the illicit drugs, the amphetamines, anabolic steroids and growth hormone we also have to consider the legal consequences of their use. Growth hormone and anabolic steroids, drugs used mainly by athletes, have been classified as controlled substances in North America and other places.
In addition to the legal ramifications of growth hormone and anabolic steroid use, there are the health risks inherent in how these compounds are obtained and used. Think of the main source of these drugs. People run the risk of getting counterfeit drugs that may be tainted with who knows what and putting themselves at further risk.
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